Tuberculosis research reports- TB drugs increases susceptibility to Mtb-reinfection

Tuberculosis treatment in recent times should give permanent cure for TB infection which is being caused by Mycobacterium tuberculosis (Mtb). But the TB research was worried after knowing that there is no prevention for reinfection. Here are the reasons why?

A recent publication revealed that the anti-TB drugs changes the activity of gut microbiota and increases the susceptibility to Mtb infection. Gut microbiota are crucial to keep us healthy; they involve in food digestion, fights pathogenic microbes and protects our immune system. Recent research has reported that chronic use of antibiotic (TB Drugs) leads to disruption of this microbiome, which can in turn lead to dysregulation of the immune system. It remains unclear, however, whether changes in the composition of the microbes living in our gut have an influence on TB infection.

In an experimental treatment for Tuberculosis with anti-TB drugs like isoniazid, rifampicin and pyrazinamide for a period of eight weeks, they found that all of them significantly changed the composition of the specimen gut microbiome, but the only specimen treated with isoniazid combined with pyrazinamide showed an increase in susceptibility to Mtb infection. This study can be completely understood by knowing the Epidemiology of TB, relationship of Lungs to gut microbiota.

To know about these details visit Mtb reinfection and to share your scientific experiences on such conditions take part in workshops and symposium carried on rare diseases (Tuberculosis is said to be one of the rare diseases). We believe that Euro Epidemiology congress will give some details on advanced research on these deadly and dangerous diseases and controllable disorders for better human healthcare.